BACH2 and CWF19L2

Data Source:
BioGRID (two hybrid)

		BACH2	CWF19L2
Description		BTB domain and CNC homolog 2	CWF19 like cell cycle control factor 2
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol	Post-mRNA Release Spliceosomal Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Import Into Nucleus Primary Adaptive Immune Response Involving T Cells And B Cells	MRNA Splicing, Via Spliceosome
Pathways
Drugs
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Basophil count ( 32888494) Celiac disease ( 22057235 20190752 24999842 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive performance ( 20125193) Crohn's disease ( 28067908 21102463) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) General risk tolerance (MTAG) ( 30643258) Graves' disease ( 21841780 22922229) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Interleukin-6 levels ( 22205395) Keratinocyte cancer (MTAG) ( 31174203) Latent autoimmune diabetes ( 30254083) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602 21833088) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Primary central nervous system lymphoma ( 31102405) Primary sclerosing cholangitis ( 23603763 27992413) Red blood cell count ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Rheumatoid arthritis ( 30572963 23143596) Serum urate levels in chronic kidney disease ( 30181573) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568) Thyroid peroxidase antibody positivity ( 24586183) Thyroid peroxidase autoantibody levels in type 1 diabetes ( 21829393) Type 1 diabetes ( 21829393 25751624 19430480 30572963 18840781 18978792) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Coronary artery disease ( 29212778) Cortex volume ( 31530798) Diastolic blood pressure ( 27841878) Fourth ventricle volume ( 31530798) Parkinson's disease progression (cognitive) ( 33111402) Pars opercularis volume ( 31530798) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		46 interacting genes: ANKRD55 AP1M1 BAHD1 BATF3 CBX8 CCDC185 CENPP CFAP58 CTSZ CWF19L2 DDIT3 ELOA ENPP7 FAM161A FARS2 FOSL2 HMG20A INSYN2A KAT5 LUZP4 MAFF MAFG MAFK MCRS1 MLX NFE2L1 NFE2L3 NXF1 PATZ1 PSMC5 RPL9 RPP25 SCNM1 SLC43A1 SMYD1 TCEA2 TRAF4 TRIM42 TSHZ2 TULP3 ZBTB24 ZBTB34 ZNF124 ZNF438 ZNF774 ZNF792	80 interacting genes: ABLIM3 APP AXIN2 BACH2 BRCA1 CALCOCO1 CALCOCO2 CARD10 CARD9 CCDC102B CCDC136 CCDC57 CCDC88B CEP63 CEP70 CEP76 CFAP53 CNTROB CWF19L1 DES DISC1 EXOC8 FAM9B FCHO1 FSD2 FXR1 FXR2 GAS8 GFAP GOLGA2 GOLGA6L9 GRIPAP1 HOMER3 HOOK1 HOOK2 HSF2BP IKBKG IKZF1 KANK2 KASH5 KIF24 KIFC3 KRT40 LHX3 LHX9 LIMS1 LMNA LZTS1 LZTS2 M1AP MAD1L1 MEOX1 MTUS2 NAB2 NDEL1 PDE4DIP PIBF1 PICK1 PSTPIP1 RINT1 SF3B4 SNW1 STX11 TAX1BP1 TBC1D1 TFIP11 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM37 TRIM54 TRIM9 VIM VPS52 ZBTB8A ZMYND12 ZNF35 ZNF655 ZRANB1
Entrez ID		60468	143884
HPRD ID		12012	13102
Ensembl ID		ENSG00000112182	ENSG00000152404
Uniprot IDs		Q9BYV9	Q2TBE0
PDB IDs		3OHU 3OHV	6ID0 6ID1
Enriched GO Terms of Interacting Partners?
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