RNF2 and ERG

Data Source:
BioGRID (pull down)

		RNF2	ERG
Description		ring finger protein 2	ETS transcription factor ERG
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Chromatin Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Germ Cell Development Anterior/posterior Axis Specification Gene Expression Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Multicellular Organism Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases			Ewing's sarcoma Prostate cancer
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)	Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 27386562) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)
Interacting Genes		59 interacting genes: ABCB1 AMBRA1 AUTS2 BAALC BMI1 CASP3 CASP9 CBX2 CBX4 DYSF ERG H2AC18 H2AC20 H2AC4 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF3 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SIK1 SMURF2 SSX2 TARDBP TFCP2 TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W USP11 USP19 WASHC1 YAF2	74 interacting genes: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HERC2 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 PVT1 RCC2 RING1 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SPOP STUB1 SYN1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X XRN2
Entrez ID		6045	2078
HPRD ID		07028	01298
Ensembl ID		ENSG00000121481	ENSG00000157554
Uniprot IDs		Q99496	A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O	1SXE 4IRG 4IRH 4IRI 5YBC 5YBD
Enriched GO Terms of Interacting Partners?
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