ERG and PVT1

Data Source:
BioGRID (unspecified method)

		ERG	PVT1
Description		ETS transcription factor ERG	Pvt1 oncogene
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Multicellular Organism Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Ewing's sarcoma Prostate cancer
GWAS		Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 27386562) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Allergic sensitization ( 30013184 23817571) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basophil count ( 32888494) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 32581322) Diffuse large B cell lymphoma ( 25261932) End-stage renal disease ( 17395743) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Follicular lymphoma ( 25279986) Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction ( 32080893) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hodgkin's lymphoma ( 21037568) Immunoglobulin A ( 20694011) Lung cancer ( 28604730) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21833088) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Orofacial clefts ( 19270707) Pancreatic cancer ( 25086665) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Psychosis (atypical) ( 24132900) Renal cell carcinoma ( 24220699) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Seasonality ( 25562672) Selective IgA deficiency ( 27723758) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30297969) Urinary bladder cancer ( 24861552) Urinary calcium excretion ( 31993563) Waist-hip ratio ( 28552196) White blood cell count ( 32888494 27863252)
Interacting Genes		74 interacting genes: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HERC2 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 PVT1 RCC2 RING1 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SPOP STUB1 SYN1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X XRN2	5 interacting genes: ERG KRT9 POTEKP RBM25 RPS16
Entrez ID		2078	5820
HPRD ID		01298
Ensembl ID		ENSG00000157554	ENSG00000249859
Uniprot IDs		A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308
PDB IDs		1SXE 4IRG 4IRH 4IRI 5YBC 5YBD
Enriched GO Terms of Interacting Partners?
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