BCL3 and GTF2A1

Data Source:
HPRD (in vitro)

		BCL3	GTF2A1
Description		BCL3 transcription coactivator	general transcription factor IIA subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Midbody Protein-containing Complex Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytosol Transcription Preinitiation Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein-macromolecule Adaptor Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity
	Biological Process	Follicular Dendritic Cell Differentiation Marginal Zone B Cell Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Germinal Center Formation Transcription, DNA-templated Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Response To Virus Response To UV-C Antimicrobial Humoral Response Extracellular Matrix Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production T-helper 1 Type Immune Response Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Defense Response To Protozoan Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process T-helper 2 Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Spleen Development Regulation Of DNA Binding Maintenance Of Protein Location In Nucleus Regulation Of NIK/NF-kappaB Signaling	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II
Pathways			HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644 24755620) Alzheimer's disease (late onset) ( 23565137) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Asthma ( 32296059) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Neutrophil count ( 32888494) Night sleep phenotypes ( 27126917) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		35 interacting genes: AKT1 ANKRD28 BARD1 CHUK COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK1 MAPK3 MAPRE1 N4BP2 NCOA1 NFKB1 NFKB2 PIR RAB9A RUVBL2 RXRA SHC1 TBP TRAF6	26 interacting genes: BCL3 BIRC7 CREB1 CSNK2A1 CSNK2A2 GTF2A2 GTF2E1 GTF2E2 GTF2F1 HMGB1 NCOA6 NFYA PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 SP4 TAF1 TAF4 TAF4B TASP1 TBP TBPL1 TRIP4
Entrez ID		602	2957
HPRD ID		00179	02748
Ensembl ID		ENSG00000069399	ENSG00000165417
Uniprot IDs		B7Z3N9 P20749	P52655
PDB IDs		1K1A 1K1B	1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?