RGS12 and PLCB1

Data Source:
HPRD (in vitro)

		RGS12	PLCB1
Description		regulator of G protein signaling 12	phospholipase C beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Synapse	Chromatin Nucleus Cytoplasm Cytosol Nuclear Speck Nuclear Membrane Protein-containing Complex Extracellular Exosome Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Enzyme Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	G2/M Transition Of Mitotic Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Cerebral Cortex Development Positive Regulation Of Interleukin-12 Production Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Developmental Growth Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation Positive Regulation Of CD24 Production
Pathways		G alpha (i) signalling events G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Adult body size ( 32376654) Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Hepatocyte growth factor levels ( 25998175) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Platelet count ( 29403010) Serum albumin level ( 29403010) Total cholesterol levels ( 29403010) Tuberculosis ( 29036319) Worry too long after an embarrassing experience ( 29500382)	Adverse response to drug ( 30420678) Chronic kidney disease ( 26420894) Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28135244) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lateral ventricle temporal horn volume ( 31530798) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neuritic plaque ( 31497858) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to irinotecan in non-small-cell lung cancer ( 22664479) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Social communication problems ( 24564958) Suicide ideation score in major depressive disorder ( 26079190) White blood cell count ( 32888494 27863252)
Interacting Genes		17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG	18 interacting genes: CEP76 CTBP1 CTBP2 GNAQ GRK2 MAPK1 MAPK3 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SLC9A3R1 SPTBN1 TFCP2 TRPC3 TRPM7
Entrez ID		6002	23236
HPRD ID		03943	06177
Ensembl ID		ENSG00000159788	ENSG00000182621
Uniprot IDs		O14924	Q9NQ66
PDB IDs		2EBZ 2KV8
Enriched GO Terms of Interacting Partners?
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