PLCB1 and PARD3

Data Source:
HPRD (in vivo)

		PLCB1	PARD3
Description		phospholipase C beta 1	par-3 family cell polarity regulator
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Nuclear Speck Nuclear Membrane Protein-containing Complex Extracellular Exosome Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Apical Plasma Membrane Cell Junction Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Apical Junction Complex Axonal Growth Cone
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Enzyme Binding Identical Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Cerebral Cortex Development Positive Regulation Of Interleukin-12 Production Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Developmental Growth Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation Positive Regulation Of CD24 Production	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Cycle Cell Adhesion Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Centrosome Localization Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Adverse response to drug ( 30420678) Chronic kidney disease ( 26420894) Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28135244) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lateral ventricle temporal horn volume ( 31530798) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neuritic plaque ( 31497858) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to irinotecan in non-small-cell lung cancer ( 22664479) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Social communication problems ( 24564958) Suicide ideation score in major depressive disorder ( 26079190) White blood cell count ( 32888494 27863252)	Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)
Interacting Genes		18 interacting genes: CEP76 CTBP1 CTBP2 GNAQ GRK2 MAPK1 MAPK3 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SLC9A3R1 SPTBN1 TFCP2 TRPC3 TRPM7	29 interacting genes: CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN YWHAB YWHAG YWHAH YWHAZ
Entrez ID		23236	56288
HPRD ID		06177	05994
Ensembl ID		ENSG00000182621	ENSG00000148498
Uniprot IDs		Q9NQ66	Q8TEW0
PDB IDs			2KOM
Enriched GO Terms of Interacting Partners?
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