TRIM27 and CLK2

Data Source:
BioGRID (two hybrid)

		TRIM27	CLK2
Description		tripartite motif containing 27	CDC like kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Early Endosome Cytosol PML Body Retromer Complex Nuclear Membrane	Nucleus Nucleoplasm Nuclear Body Nuclear Speck
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Negative Regulation Of Adaptive Immune Response Negative Regulation Of Protein Kinase Activity Spermatogenesis Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Protein Localization Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Calcium Ion Import	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways		SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
Drugs			Fostamatinib
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 32296059 31619474 29273806) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Childhood and early adolescence aggressive behavior ( 26087016) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate in diabetes ( 31451708) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Lung cancer in ever smokers ( 28604730) Neurociticism ( 29500382) Platelet aggregation ( 20526338) Pre-treatment viral load in HIV-1 infection ( 31219150) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Social communication problems ( 24047820) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		354 interacting genes: ABCA1 ABCF3 ABHD17A ACSF3 AEN AMMECR1 AMOTL2 AP1M1 ARHGEF3 ARHGEF5 ARID5A ARIH2 ARMC7 ARNT2 ARPIN ATPAF2 ATXN7 AXIN1 BABAM1 BAG1 BAG3 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL C1orf109 CAPN7 CARD10 CATSPER1 CBX8 CCDC102B CCDC185 CCDC187 CCDC198 CCDC87 CCDC92 CCHCR1 CDC20B CDC23 CDC7 CDK18 CDKL3 CFAP206 CHCHD3 CHD4 CHUK CKS1B CLK2 CNNM3 COX5B CPNE2 CPNE7 CREB5 CSRP2 CWF19L2 DBF4B DCX DDX6 DGCR6 DMRT3 DNMT1 DTNB DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4A3 EIF4E EIF4E2 ENKD1 EPC1 ERCC3 EXOC8 FAM110A FAM126A FAM126B FAM161A FAM193B FAM214A FAM214B FAM83A FAM90A1 FANCM FARS2 FASTKD5 FBF1 FBXL19 FBXW5 FHL3 FNDC11 FOXB1 FOXC2 FXYD6 GADD45GIP1 GAS2L2 GATAD2B GCC2-AS1 GEM GFAP GFI1B GFM2 GLYCTK GNE GNPDA2 GPANK1 GPKOW GRB14 GRB2 GSE1 GTF2F1 HAPLN2 HAUS1 HCK HDAC1 HDAC4 HGS HIP1R HNRNPLL HOXB5 HOXB9 HOXC8 HR IGFN1 IKBKB IKBKE IL16 ILF2 ILK INO80B INPP5J IP6K3 IQCE IQCN IQUB JOSD1 KANSL1 KAT14 KAT5 KCTD15 KCTD9 KIF1A KIF9 KIFC3 KRT3 KRT75 KRT76 LAGE3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMNB2 LMO1 LMO4 LNX1 LONRF1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAGOHB MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MSRB1 MTMR6 MVP MYO15B NCK2 NCOA1 NDE1 NDEL1 NEBL NEDD9 NEIL2 NEK6 NELFE NIF3L1 NME7 NOTCH2NLA NR1D2 NTAQ1 NUDT21 OAS1 OTUB2 P2RX7 PIAS1 PIAS2 PIAS3 PIAS4 PIBF1 PIMREG PIN1 PKN1 PLEKHN1 PML POLE2 POLR1C POLR3C POM121 PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF18 PRPF31 PRR35 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L QARS1 RAB29 RAMAC RB1 RBM23 RBM41 RBX1 RCOR3 REL RHPN1 RIBC1 RIN1 RNF213 RNF25 RNF6 RSPH14 RXRB SCNM1 SDCBP SH2D4A SIAH1 SIRPA SLC15A3 SMARCB1 SMARCD1 SMG9 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SRSF2 STAMBPL1 STK16 STK25 STK26 SYNGAP1 SYT17 SYT6 TACO1 TBC1D22B TBK1 TCEA2 TCEANC TCHP TEAD4 TEX33 THOC1 TLE5 TMSB4X TMSB4XP6 TNS4 TP53 TPM3 TPRKB TRAF4 TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM50 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBASH3A UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UBL5 UCHL3 UCHL5 UHRF2 USE1 USP2 UTP14C UTP23 VEZF1 VPS25 VPS28 VPS9D1 WT1-AS XPA YJU2 ZBTB16 ZC2HC1C ZFC3H1 ZFHX3 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF384 ZNF414 ZNF417 ZNF446 ZNF572 ZNF580 ZNF581 ZNF587 ZNF688 ZNF79	53 interacting genes: AKT1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUZP4 MRPL4 NXF1 PRM1 PRPF38A PTPN1 RBM39 RNF8 RNPS1 RSRP1 SDCBP SNIP1 SNRNP70 SRPK2 SRRM1 SRSF3 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21
Entrez ID		5987	1196
HPRD ID		15996	04289
Ensembl ID		ENSG00000204713	ENSG00000176444
Uniprot IDs		A0A1U9X8R9 P14373	A8K7I0 B7Z8N6 P49760
PDB IDs			3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?
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