REST and CDYL

Data Source:
BioGRID (pull down)

		REST	CDYL
Description		RE1 silencing transcription factor	chromodomain Y like
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex	Nucleus Chromosome Cytoplasm Nuclear Speck
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Metal Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Crotonyl-CoA Hydratase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Hypoxia Response To Ischemia Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Aldosterone Biosynthetic Process Somatic Stem Cell Population Maintenance Cellular Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Cardiac Muscle Cell Myoblast Differentiation Histone H4 Deacetylation Cellular Response To Electrical Stimulus Cellular Response To Glucocorticoid Stimulus Neuronal Stem Cell Population Maintenance Modification Of Synaptic Structure Positive Regulation Of Stem Cell Population Maintenance Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Amniotic Stem Cell Differentiation	Spermatogenesis Spermatid Development Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome Negative Regulation Of Peptidyl-lysine Crotonylation
Pathways		HDACs deacetylate histones Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age-related macular degeneration ( 21909106) Coronary artery disease ( 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 25429064 31562340) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Migraine ( 27322543) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 29403010) Plateletcrit ( 32888494) Response to bleomycin (chromatid breaks) ( 21106707) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) White blood cell count ( 32888494)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 28552196) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Red cell distribution width ( 32888494) Response to ketogenic dietary therapies in epilepsy ( 30009487) Weight ( 28552196)
Interacting Genes		10 interacting genes: AURKA CDYL GTF2B HTT MAPK1 PLK1 RCOR1 SIN3B SUB1 TBP	6 interacting genes: H3-4 HDAC1 HDAC2 HTRA1 REST TTC9C
Entrez ID		5978	9425
HPRD ID		08990	04803
Ensembl ID		ENSG00000084093	ENSG00000153046
Uniprot IDs		A0A1W2PQA1 Q13127	Q9Y232
PDB IDs		2CZY 6DU2 6DU3	2DNT 2GTR
Enriched GO Terms of Interacting Partners?
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