REST and RCOR1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		REST	RCOR1
Description		RE1 silencing transcription factor	REST corepressor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex DNA Repair Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Metal Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Hypoxia Response To Ischemia Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Aldosterone Biosynthetic Process Somatic Stem Cell Population Maintenance Cellular Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Cardiac Muscle Cell Myoblast Differentiation Histone H4 Deacetylation Cellular Response To Electrical Stimulus Cellular Response To Glucocorticoid Stimulus Neuronal Stem Cell Population Maintenance Modification Of Synaptic Structure Positive Regulation Of Stem Cell Population Maintenance Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Amniotic Stem Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Blood Coagulation Viral Process Histone Deacetylation Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Histone H4 Deacetylation
Pathways		HDACs deacetylate histones Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS	HDACs deacetylate histones Regulation of PTEN gene transcription Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age-related macular degeneration ( 21909106) Coronary artery disease ( 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 25429064 31562340) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Migraine ( 27322543) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 29403010) Plateletcrit ( 32888494) Response to bleomycin (chromatid breaks) ( 21106707) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) White blood cell count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 22139419 32888494 27863252) Plateletcrit ( 32888494 27863252)
Interacting Genes		10 interacting genes: AURKA CDYL GTF2B HTT MAPK1 PLK1 RCOR1 SIN3B SUB1 TBP	12 interacting genes: CTBP1 FOXK2 H3-4 HDAC2 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 SUMO2 ZMYM2
Entrez ID		5978	23186
HPRD ID		08990	09645
Ensembl ID		ENSG00000084093	ENSG00000089902
Uniprot IDs		A0A1W2PQA1 Q13127	Q9UKL0
PDB IDs		2CZY 6DU2 6DU3	2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5H6Q 5H6R 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6K3E 6KGK 6KGL 6KGM 6KGN 6S35 6TE1 6VYP 6W4K
Enriched GO Terms of Interacting Partners?
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