RDH5 and RGR

Data Source:
HPRD (in vivo)

		RDH5	RGR
Description		retinol dehydrogenase 5	retinal G protein coupled receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Membrane Cell Body	Photoreceptor Outer Segment Integral Component Of Plasma Membrane
	Molecular Function	Retinol Dehydrogenase Activity Protein Homodimerization Activity Androsterone Dehydrogenase Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity
	Biological Process	Retinoid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process Response To Stimulus	G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Detection Of Visible Light Protein-chromophore Linkage Cellular Response To Light Stimulus
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway	G alpha (i) signalling events Opsins
Drugs		NADH Vitamin A
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	Retinitis pigmentosa (RP)
GWAS		Advanced age-related macular degeneration ( 26691988) High myopia ( 31816047) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	High myopia ( 31816047) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ORC4 RGR RLBP1	7 interacting genes: ADRB2 CCR2 F2RL1 KIFBP RDH5 TRIM55 TRIM63
Entrez ID		5959	5995
HPRD ID		03370	02642
Ensembl ID		ENSG00000135437	ENSG00000148604
Uniprot IDs		A0A024RB18 Q92781	A0A0S2Z494 A0A0S2Z498 P47804
PDB IDs
Enriched GO Terms of Interacting Partners?
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