GNB4 and GNG4

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (two hybrid)

		GNB4	GNG4
Description		G protein subunit beta 4	G protein subunit gamma 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Extracellular Exosome	Heterotrimeric G-protein Complex Plasma Membrane G-protein Beta/gamma-subunit Complex Extracellular Exosome
	Molecular Function	Protein Binding G-protein Gamma-subunit Binding Protein-containing Complex Binding	Protein Binding G-protein Beta-subunit Binding
	Biological Process	Protein Folding G Protein-coupled Receptor Signaling Pathway Substantia Nigra Development	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Growth
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Heart rate ( 23583979) Resting heart rate ( 29769521 27798624)	Aging traits ( 17903295) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Type 2 diabetes ( 30297969)
Interacting Genes		18 interacting genes: GNAI1 GNAI2 GNAI3 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MTNR1A MTNR1B PTEN	9 interacting genes: FHL2 GNB1 GNB2 GNB3 GNB4 GNB5 RAF1 TFIP11 USHBP1
Entrez ID		59345	2786
HPRD ID		09973	11978
Ensembl ID		ENSG00000114450	ENSG00000168243
Uniprot IDs		Q9HAV0	B1APZ0 P50150
PDB IDs
Enriched GO Terms of Interacting Partners?
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