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RAG1 and SNX6
Data Source:
BioGRID
(affinity chromatography technology)
RAG1
SNX6
Description
recombination activating 1
sorting nexin 6
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
DNA Recombinase Complex
Endodeoxyribonuclease Complex
Nucleus
Cytoplasm
Endosome
Cytosol
Retromer Complex
Retromer, Tubulation Complex
Early Endosome Membrane
Tubular Endosome
Molecular Function
DNA Binding
Endonuclease Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Histone Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Double-stranded DNA Endodeoxyribonuclease Activity
Protein Binding
Dynactin Binding
Phosphatidylinositol Binding
Protein Homodimerization Activity
Biological Process
Adaptive Immune Response
Pre-B Cell Allelic Exclusion
DNA Recombination
Immune Response
Visual Learning
Histone Monoubiquitination
B Cell Differentiation
T Cell Differentiation In Thymus
V(D)J Recombination
T Cell Homeostasis
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of T Cell Differentiation
Thymus Development
Protein Autoubiquitination
Negative Regulation Of Thymocyte Apoptotic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Regulation Of Behavioral Fear Response
Intracellular Protein Transport
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Regulation Of Macroautophagy
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Retrograde Transport, Endosome To Golgi
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Histamine Secretion By Mast Cell
Cellular Response To Amyloid-beta
Pathways
Interleukin-7 signaling
MAPK6/MAPK4 signaling
Drugs
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS
Rheumatoid arthritis (
24390342
)
Atrial fibrillation (
29892015
)
Celiac disease (
23936387
)
Diastolic blood pressure (
30224653
)
Normal facial asymmetry (angle of surface orientation score) (
30631343
)
Interacting Genes
17 interacting genes:
APP
DCAF1
H2AC20
H2BC21
H3-4
H3C1
H4-16
HMGB1
HMGB2
KPNA1
KPNA2
RAG2
UBC
UBE2C
UBE2D1
UBE2D2
UBE2H
25 interacting genes:
ACVR2B
ACVRL1
BMPR1B
BRCA1
BRMS1
CALM1
COIL
CSNK2A2
DISC1
EGFR
ESR1
INSR
LEPR
NDEL1
OPTN
PDGFRA
PIM1
SNX1
SNX2
SNX4
TEX11
TGFBR1
TGFBR2
TNIK
TPT1
Entrez ID
5896
58533
HPRD ID
01556
12086
Ensembl ID
ENSG00000166349
ENSG00000129515
Uniprot IDs
P15918
A0A0A0MRI2
Q9UNH7
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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