SNX6 and SNX2

Data Source:
HPRD (in vivo, in vitro)

		SNX6	SNX2
Description		sorting nexin 6	sorting nexin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Tubular Endosome	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Protein-containing Complex
	Molecular Function	Protein Binding Dynactin Binding Phosphatidylinositol Binding Protein Homodimerization Activity	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Intracellular Protein Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Macroautophagy Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Histamine Secretion By Mast Cell Cellular Response To Amyloid-beta	Intracellular Protein Transport Endocytosis Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis
Pathways			Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Celiac disease ( 23936387) Diastolic blood pressure ( 30224653) Normal facial asymmetry (angle of surface orientation score) ( 30631343)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Plateletcrit ( 32888494) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: ACVR2B ACVRL1 BMPR1B BRCA1 BRMS1 CALM1 COIL CSNK2A2 DISC1 EGFR ESR1 INSR LEPR NDEL1 OPTN PDGFRA PIM1 SNX1 SNX2 SNX4 TEX11 TGFBR1 TGFBR2 TNIK TPT1	28 interacting genes: ACVR1B ACVR2B ARL6IP1 C1orf122 CENPQ CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET MTIF3 NFYC PAK6 PDGFRA PDGFRB PLIN3 PNKP SNX1 SNX32 SNX4 SNX5 SNX6 TMEM239 YIF1A ZNF202
Entrez ID		58533	6643
HPRD ID		12086	09332
Ensembl ID		ENSG00000129515	ENSG00000205302
Uniprot IDs		A0A0A0MRI2 Q9UNH7	O60749
PDB IDs
Enriched GO Terms of Interacting Partners?
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