RAD23B and UBA2

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		RAD23B	UBA2
Description		RAD23 homolog B, nucleotide excision repair protein	ubiquitin like modifier activating enzyme 2
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol XPC Complex	Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Proteasome Binding	Magnesium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Transferase Activity SUMO Activating Enzyme Activity SUMO Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Protein Folding Spermatogenesis Protein Deubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Global Genome Nucleotide-excision Repair Cellular Response To Interleukin-7	Protein Sumoylation Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS		Body mass index ( 20966902) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 21263130) Chronotype ( 30696823) Cutaneous malignant melanoma ( 26237428) Melanoma ( 28212542) Prostate cancer ( 23023329)
Interacting Genes		30 interacting genes: ADRM1 ATXN3 CALM1 DBI DEAF1 HIP1 HMGB1 MKRN1 MLH1 MPG NGLY1 PAQR3 PAX3 PNMA5 POU6F2 PSMC2 PSMD4 PUF60 RPA1 RSC1A1 TAX1BP1 TDG UBA2 UBB UBC UBE3A UBQLN2 USP25 XPC ZFAND5	17 interacting genes: BRIX1 CHEK1 ERCC6 ETV4 MEOX2 NEDD8 PARK7 RAD23B SAE1 SERBP1 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBD UBE2I
Entrez ID		5887	10054
HPRD ID		06772	11658
Ensembl ID		ENSG00000119318	ENSG00000126261
Uniprot IDs		B7Z4W4 P54727	Q9UBT2
PDB IDs		1P1A 1PVE 1UEL	1Y8Q 1Y8R 2PX9 3KYC 3KYD 4W5V 5FQ2 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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