RABGGTB and RAB6A

Data Source:
HPRD (in vitro)

		RABGGTB	RAB6A
Description		Rab geranylgeranyltransferase subunit beta	RAB6A, member RAS oncogene family
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Secretory Granule Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Extracellular Exosome Endosome To Plasma Membrane Transport Vesicle
	Molecular Function	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small GTPase Binding	GTPase Activity Protein Binding GTP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Phosphopantetheinylation Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Viral Process Peptidyl-cysteine Methylation Antigen Processing And Presentation Protein Localization To Golgi Apparatus Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Minus-end-directed Organelle Transport Along Microtubule
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	Pre-NOTCH Processing in Golgi Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Dimensional psychopathology (Cognitive) ( 29496196) Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A RABGGTA SH3GLB1 TAFA1 TMEM25 WDR4	21 interacting genes: BICD1 BICD2 CHM CHML DCTN1 ERC1 FKBP2 GDI1 GOLGA1 GOLGA2 GOLGA4 GORAB KIF20A OCRL PMM1 RAB7A RABAC1 RABGAP1 RABGGTB SYTL5 TMF1
Entrez ID		5876	5870
HPRD ID		01532	01543
Ensembl ID		ENSG00000137955	ENSG00000175582
Uniprot IDs		A8KAJ2 P53611 Q6IB63	A0A024R5H8 A0A024R5J5 P20340 Q53ET8
PDB IDs		6J6X 6J74 6J7F 6J7X 6O60	1YZQ 2GIL 3BBP 3CWZ 4DKX 5LEF
Enriched GO Terms of Interacting Partners?
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