RAB5A and RABGGTB

Data Source:
HPRD (in vitro)

		RAB5A	RABGGTB
Description		RAB5A, member RAS oncogene family	Rab geranylgeranyltransferase subunit beta
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Neuronal Cell Body Terminal Bouton Intracellular Membrane-bounded Organelle Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane Postsynaptic Early Endosome Anchored Component Of Synaptic Vesicle Membrane	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Intracellular Protein Transport Endocytosis Phagocytosis Blood Coagulation Regulation Of Endocytosis Synaptic Vesicle Recycling Viral RNA Genome Replication Post-translational Protein Modification Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Endosome Size Regulation Of Filopodium Assembly Membrane Organization Amyloid-beta Clearance By Transcytosis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly	Cellular Protein Modification Process Visual Perception Protein Phosphopantetheinylation Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification
Pathways		Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Factors involved in megakaryocyte development and platelet production	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation
Drugs		L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate	N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)	Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		35 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL	20 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A RABGGTA SH3GLB1 TAFA1 TMEM25 WDR4
Entrez ID		5868	5876
HPRD ID		01542	01532
Ensembl ID		ENSG00000144566	ENSG00000137955
Uniprot IDs		A0A024R2K1 P20339	A8KAJ2 P53611 Q6IB63
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U	6J6X 6J74 6J7F 6J7X 6O60
Enriched GO Terms of Interacting Partners?
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