DMRT3 and RFX6

Data Source:
BioGRID (two hybrid)

		DMRT3	RFX6
Description		doublesex and mab-3 related transcription factor 3	regulatory factor X6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Sex Differentiation Adult Walking Behavior Transmission Of Nerve Impulse Ventral Spinal Cord Interneuron Specification Regulation Of Odontogenesis Of Dentin-containing Tooth Male Sex Differentiation	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways			Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Dupuytren's disease ( 28886342) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Response to Homoharringtonine (cytotoxicity) ( 25628645)	Apolipoprotein A1 levels ( 32203549) Chronic obstructive pulmonary disease ( 30804561) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Inflammatory bowel disease ( 27569725) Lung cancer ( 28604730) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Prostate cancer ( 20676098 31562322 26443449) Serum total protein level ( 29403010)
Interacting Genes		86 interacting genes: AKAP8L ASPG ATN1 ATP6V0D1 C11orf1 CCNDBP1 CYSRT1 FHL3 FHL5 FOXN1 FRS3 GPSM1 GRN HSF2BP INCA1 KHDRBS3 KPRP KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP19-5 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-3 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LASP1 LMO2 MDFI MEOX2 MGAT5B MID2 MTUS2 MYOZ3 NBPF19 NFKBID NHLRC4 NOTCH2NLA OIP5 PFDN5 PLEKHF2 PLSCR1 PRDM14 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 PSME3 RBPMS REL RFX6 RUSC1 SAT1 SPAG8 TCF4 TLE5 TRAF1 TRIM23 TRIM27 TRIP6 TSC1 TTC19 UBASH3B USP54 WWOX YPEL3 ZFY ZMYND12 ZNF438	41 interacting genes: AGXT ARNT2 CATSPER1 CCNK CSTF2 CYFIP1 DGCR6 DMRT3 DTX2 DUSP21 ESR2 FHL3 FRS3 HGS KCTD9 KIF1A LGALS4 LMO3 MEMO1 NEDD9 PATZ1 PITX1 PLEKHN1 PPP1R32 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 TEKT3 TEKT4 TENT5B TLE5 USP2 VPS37C ZMYND19 ZNF688
Entrez ID		58524	222546
HPRD ID		16827	11490
Ensembl ID		ENSG00000064218	ENSG00000185002
Uniprot IDs		Q9NQL9	Q8HWS3
PDB IDs
Enriched GO Terms of Interacting Partners?
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