DLGAP3 and SHANK2

Data Source:
BioGRID (two hybrid)

		DLGAP3	SHANK2
Description		DLG associated protein 3	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Neuromuscular Junction Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding Molecular Adaptor Activity	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Signaling Regulation Of Postsynaptic Neurotransmitter Receptor Activity Modification Of Synaptic Structure	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Glomerular filtration rate in chronic kidney disease ( 26420894) Nicotine dependence ( 28440896)	Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		15 interacting genes: DLG1 DLG2 DLG3 DLG4 DLGAP1 GOLGA2 KANK2 KRTAP1-3 KRTAP5-2 MAGEA6 MAGI2 PTK2 PTK2B SHANK2 SHANK3	19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		58512	22941
HPRD ID		18935	04479
Ensembl ID		ENSG00000116544	ENSG00000162105
Uniprot IDs		O95886	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs
Enriched GO Terms of Interacting Partners?
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