PTPRS and RAB35

Data Source:
HPRD (two hybrid)

		PTPRS	RAB35
Description		protein tyrosine phosphatase receptor type S	RAB35, member RAS oncogene family
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Axon Growth Cone Perikaryon Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Cytosol Plasma Membrane Clathrin-coated Pit Endosome Membrane Clathrin-coated Vesicle Membrane Cell Projection Membrane Melanosome Intercellular Bridge Clathrin-coated Endocytic Vesicle Recycling Endosome Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding GDP Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Synaptic Membrane Adhesion	Mitotic Cytokinesis Protein Localization Protein Transport Endosomal Transport Antigen Processing And Presentation Neuron Projection Development Endocytic Recycling Rab Protein Signal Transduction Protein Localization To Endosome Plasma Membrane To Endosome Transport Cellular Response To Nerve Growth Factor Stimulus
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Alendronic acid Etidronic acid
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Heel bone mineral density ( 30598549)
Interacting Genes		27 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	9 interacting genes: APP CALCOCO2 CBR3 GNPAT IDH3B PTPRS TBPL1 TRIM54 WDCP
Entrez ID		5802	11021
HPRD ID		03344	05010
Ensembl ID		ENSG00000105426	ENSG00000111737
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	Q15286
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX	3TW8 6EKK 6IF2 6IF3
Enriched GO Terms of Interacting Partners?
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