PTPRS and GPC6

Data Source:
BioGRID (pull down)

		PTPRS	GPC6
Description		protein tyrosine phosphatase receptor type S	glypican 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Axon Growth Cone Perikaryon Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Extracellular Space Nucleus Golgi Lumen Plasma Membrane Cell Surface Lysosomal Lumen Synapse Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	Protein Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Synaptic Membrane Adhesion	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Signal Transduction Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Protein Localization To Membrane Regulation Of Presynapse Assembly
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs		Alendronic acid Etidronic acid
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Alzheimer's disease (cognitive decline) ( 23535033) Arterial stiffness index ( 31235810) Attention deficit hyperactivity disorder ( 18839057) Bitter alcoholic beverage consumption ( 31046077) Blood pressure (smoking interaction) ( 25189868) Breast size ( 22747683) Chronotype ( 30696823) Disc degeneration (lumbar) ( 22993228) Heel bone mineral density ( 30598549 28869591) Mitochondrial DNA copy number (white blood cells) ( 30704525) Morning person ( 30696823) Neuroticism (age interaction) ( 20634892) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 26545240) Refractive error ( 32231278) Renal sinus fat ( 22044751) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tonometry ( 17903302) Visceral fat ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		27 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	1 interacting genes: PTPRS
Entrez ID		5802	10082
HPRD ID		03344	05099
Ensembl ID		ENSG00000105426	ENSG00000183098
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	Q9Y625
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX
Enriched GO Terms of Interacting Partners?
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