PTPRE and KCNA5

Data Source:
HPRD (in vitro)

		PTPRE	KCNA5
Description		protein tyrosine phosphatase receptor type E	potassium voltage-gated channel subfamily A member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Cell Surface Intercalated Disc Integral Component Of Membrane Z Disc Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding	Signaling Receptor Binding Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Bundle Of His Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Repolarization Scaffold Protein Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway	Response To Hypoxia Potassium Ion Transport Notch Signaling Pathway Response To Mechanical Stimulus Response To Organic Substance Regulation Of Vasoconstriction Regulation Of Membrane Potential Response To Hydrogen Peroxide Regulation Of Potassium Ion Transport Regulation Of Insulin Secretion Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Response To Hyperoxia Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Bundle Of His Cell Action Potential Membrane Repolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation
Pathways			Voltage gated Potassium channels
Drugs		Alendronic acid Tiludronic acid	Enflurane Promethazine Miconazole Vernakalant Dalfampridine Isavuconazole
Diseases			Atrial fibrillation
GWAS		Response to amphetamines ( 22952603) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)	Longevity ( 30294719)
Interacting Genes		10 interacting genes: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1	11 interacting genes: ACTN2 DLG1 DLG4 ERBIN KCNA2 PTPRE SNTA1 SRC TMEM107 TNK2 UBE2I
Entrez ID		5791	3741
HPRD ID		02956	08888
Ensembl ID		ENSG00000132334	ENSG00000130037
Uniprot IDs		A8K2Z9 P23469 Q96P81	P22460
PDB IDs		2JJD 6D3F 6D4D 6D4F
Enriched GO Terms of Interacting Partners?
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