PTPN14 and JUP

Data Source:
HPRD (in vitro)

		PTPN14	JUP
Description		protein tyrosine phosphatase non-receptor type 14	junction plakoglobin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Coregulator Activity Protein Tyrosine Phosphatase Activity Protein Binding Receptor Tyrosine Kinase Binding	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Lymphangiogenesis Regulation Of Transcription, DNA-templated Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Export From Nucleus Cellular Response To Cytokine Stimulus	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Migration Keratinization Adherens Junction Organization Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Cornification Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Interleukin-37 signaling	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases		Choanal atresia and lymphedema	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Birth weight ( 31043758) Bone mineral density (hip) ( 30172743) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 28552196 25429064 31562340) Lipid traits ( 24386095) Plasma thyroid-stimulating hormone levels ( 24722205)	Heel bone mineral density ( 30598549 28869591)
Interacting Genes		8 interacting genes: AMOT CDH1 CTNNA2 CTNNB1 JUP TJP1 TRIP6 YWHAG	52 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 ZFYVE9
Entrez ID		5784	3728
HPRD ID		04402	01414
Ensembl ID		ENSG00000152104	ENSG00000173801
Uniprot IDs		A8K6H6 Q15678	A0A0S2Z487 P14923
PDB IDs		2BZL 6IWD 6JJW	3IFQ
Enriched GO Terms of Interacting Partners?
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