JUP and DSG2

Data Source:
HPRD (in vivo)

		JUP	DSG2
Description		junction plakoglobin	desmoglein 2
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Cornified Envelope Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Desmosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Calcium Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Migration Keratinization Adherens Junction Organization Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Cornification Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Response To Progesterone Maternal Process Involved In Female Pregnancy Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Heel bone mineral density ( 30598549 28869591)	Blood protein levels ( 30072576 29875488)
Interacting Genes		52 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 ZFYVE9	5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3
Entrez ID		3728	1829
HPRD ID		01414	00516
Ensembl ID		ENSG00000173801	ENSG00000046604
Uniprot IDs		A0A0S2Z487 P14923	Q14126
PDB IDs		3IFQ	2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7AGF 7AGG
Enriched GO Terms of Interacting Partners?
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