SH3RF1 and NAF1

Data Source:
BioGRID (two hybrid)

		SH3RF1	NAF1
Description		SH3 domain containing ring finger 1	nuclear assembly factor 1 ribonucleoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Nucleoplasm Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Identical Protein Binding Telomerase RNA Binding
	Biological Process	Neuron Migration Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	SnoRNA Guided RRNA Pseudouridine Synthesis Box H/ACA SnoRNP Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Ribosome Biogenesis RNA Stabilization Positive Regulation Of Telomerase Activity Telomerase RNA Stabilization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomerase RNA Localization To Cajal Body Telomerase Holoenzyme Complex Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Chronotype ( 30696823) Colorectal cancer ( 25023989) Hair morphology ( 19896111) Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) TPE interval (recovery after exercise) ( 32386560)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	26 interacting genes: BOLL CSNK2A1 DAB1 ELOA FAM168A HERPUD2 KRTAP19-3 KRTAP19-7 KRTAP6-1 KRTAP6-2 MAGED1 MED31 MSX2 RAMAC RBFOX2 SCARNA13 SCARNA8 SH3RF1 SNORA74A SNX33 SORBS3 SS18L1 TENT5B TLE5 UBE2I YWHAE
Entrez ID		57630	92345
HPRD ID		15335	10054
Ensembl ID		ENSG00000154447	ENSG00000145414
Uniprot IDs		Q7Z6J0	Q96HR8
PDB IDs			2EQN
Enriched GO Terms of Interacting Partners?
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