SH3RF1 and MAP3K11

Data Source:
HPRD (in vivo)

		SH3RF1	MAP3K11
Description		SH3 domain containing ring finger 1	mitogen-activated protein kinase kinase kinase 11
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Cytoplasm Centrosome Microtubule Membrane
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Neuron Migration Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Activation Of MAPK Activity Protein Phosphorylation Microtubule-based Process JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Fostamatinib
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	27 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6
Entrez ID		57630	4296
HPRD ID		15335	02502
Ensembl ID		ENSG00000154447	ENSG00000173327
Uniprot IDs		Q7Z6J0	A0A024R5E6 Q16584
PDB IDs			5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?
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