WDR48 and RAD51

Data Source:
BioGRID (pull down)

		WDR48	RAD51
Description		WD repeat domain 48	RAD51 recombinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Lysosome Late Endosome Intracellular Membrane-bounded Organelle	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Microtubule Organizing Center PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Ubiquitin Binding	Recombinase Activity Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Spermatogenesis Single Fertilization Viral Process Protein Deubiquitination Multicellular Organism Growth Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage Skin Development Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Seminiferous Tubule Development Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Deubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Regulation Of Protein Phosphorylation DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus Reciprocal Meiotic Recombination Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Interstrand Cross-link Repair Strand Invasion Response To Drug Positive Regulation Of DNA Ligation Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Negative Regulation Of G0 To G1 Transition Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing
Pathways		Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS		Metabolic syndrome ( 31589552) Social communication problems ( 24564958)	Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: FANCI NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC	94 interacting genes: - ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 C1orf112 CASP3 CASP7 CCND1 CDH13 CHD3 CHEK1 CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FIGNL1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MDC1 MMS22L MND1 MSH4 NBN NCL NELFB NXF1 PALB2 PARPBP PCSK1N PDS5B PFN1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51B RAD51C RAD52 RAD54B RAD54L RECQL5 RELA RFWD3 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TFF1 TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17
Entrez ID		57599	5888
HPRD ID		11146	01557
Ensembl ID		ENSG00000114742	ENSG00000051180
Uniprot IDs		A0A024R2L1 Q8TAF3	Q06609
PDB IDs		5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ	1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL
Enriched GO Terms of Interacting Partners?
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