WDR48 and FANCI

Data Source:
BioGRID (pull down)

		WDR48	FANCI
Description		WD repeat domain 48	FA complementation group I
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Lysosome Late Endosome Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Ubiquitin Binding	DNA Binding Protein Binding DNA Polymerase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Spermatogenesis Single Fertilization Viral Process Protein Deubiquitination Multicellular Organism Growth Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage Skin Development Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Seminiferous Tubule Development Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Deubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Cell Cycle Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair
Pathways		Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases			Fanconi anemia
GWAS		Metabolic syndrome ( 31589552) Social communication problems ( 24564958)	Height ( 25282103) Menopause (age at onset) ( 26414677) Red cell distribution width ( 32888494) Serum immune biomarker levels ( 32066700)
Interacting Genes		7 interacting genes: FANCI NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC	13 interacting genes: AKT1 APP ATR BRCA2 FANCD2 FANCL MTDH MTNR1B PIAS1 RAD51 UBL5 USP1 WDR48
Entrez ID		57599	55215
HPRD ID		11146	13339
Ensembl ID		ENSG00000114742	ENSG00000140525
Uniprot IDs		A0A024R2L1 Q8TAF3	B3KNW8 Q9NVI1
PDB IDs		5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ	6VAA 6VAD 6VAE 6VAF
Enriched GO Terms of Interacting Partners?
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