WDR48 and TOPAZ1

Data Source:
BioGRID (two hybrid)

		WDR48	TOPAZ1
Description		WD repeat domain 48	testis and ovary specific PAZ domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Lysosome Late Endosome Intracellular Membrane-bounded Organelle	Cytosol
	Molecular Function	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Ubiquitin Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Spermatogenesis Single Fertilization Viral Process Protein Deubiquitination Multicellular Organism Growth Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage Skin Development Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Seminiferous Tubule Development Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Deubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Apoptotic Process Spermatid Development Spermatocyte Division NcRNA Transcription Positive Regulation Of Meiotic Cell Cycle Phase Transition
Pathways		Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases
GWAS		Metabolic syndrome ( 31589552) Social communication problems ( 24564958)	Adult body size ( 32376654) Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		7 interacting genes: FANCI NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC
Entrez ID		57599	375337
HPRD ID		11146	19563
Ensembl ID		ENSG00000114742	ENSG00000173769
Uniprot IDs		A0A024R2L1 Q8TAF3	Q8N9V7
PDB IDs		5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ
Enriched GO Terms of Interacting Partners?
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