ARHGAP21 and ARF1

Data Source:
HPRD (in vitro, two hybrid)

		ARHGAP21	ARF1
Description		Rho GTPase activating protein 21	ADP ribosylation factor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Cytoplasmic Vesicle Membrane	Golgi Membrane Cytoplasm Late Endosome Peroxisomal Membrane Trans-Golgi Network Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Sarcomere COPI-coated Vesicle Cell Leading Edge Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding	Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Phospholipase D Activator Activity
	Biological Process	Golgi Organization Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Golgi Localization Establishment Of Golgi Localization Maintenance Of Golgi Location Organelle Transport Along Microtubule	Regulation Of Receptor Internalization Phosphatidylinositol Biosynthetic Process Cellular Copper Ion Homeostasis Intracellular Protein Transport Actin Filament Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Arp2/3 Complex-mediated Actin Nucleation Very-low-density Lipoprotein Particle Assembly Interleukin-12-mediated Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Defense Response To Virus By Virus Positive Regulation Of Protein Secretion Regulation Of Catalytic Activity Golgi To Transport Vesicle Transport Long-term Synaptic Depression Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Budding Dendritic Spine Organization Lysosomal Membrane Organization Cellular Response To Virus Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Phospholipid Metabolic Process Mitotic Cleavage Furrow Ingression
Pathways		Rho GTPase cycle	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Glycerin
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Birth weight ( 31043758) Diisocyanate-induced asthma ( 25918132) Immature fraction of reticulocytes ( 32888494) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Optic disc area ( 31798171) Optic disc size ( 31809533) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Triglyceride levels x loop diuretics use interaction ( 31806883)	Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		7 interacting genes: ARF1 EEF1D PTK2B RHOA SP1 TULP3 ZNF177	47 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 TMED10 TMED2 TMEM106A WBP11
Entrez ID		57584	375
HPRD ID		06445	00054
Ensembl ID		ENSG00000107863	ENSG00000143761
Uniprot IDs		Q5T5U3	A0A024R3Q0 P84077
PDB IDs		2DHJ 2J59 2YUY	1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE
Enriched GO Terms of Interacting Partners?
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