ARRDC3 and RAD18

Data Source:
BioGRID (two hybrid)

		ARRDC3	RAD18
Description		arrestin domain containing 3	RAD18 E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Plasma Membrane	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex
	Molecular Function	Protein Binding Beta-3 Adrenergic Receptor Binding	Y-form DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Temperature Homeostasis Protein Transport Negative Regulation Of Heat Generation Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis	DNA Repair Postreplication Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Protein Ubiquitination DNA Damage Response, Detection Of DNA Damage Protein Autoubiquitination Positive Regulation Of Chromosome Segregation Negative Regulation Of Cell Death
Pathways			Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Breast cancer ( 29059683 25038754) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Platelet distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738)	Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798)
Interacting Genes		40 interacting genes: ADRB2 BAG3 BCL6 CCDC50 CDA DCUN1D1 EFEMP2 EPN2 F2R FAM90A1 HPGDS ITCH MAGI2 MORF4L1 NEDD4L OPTN OTUB2 PDCD6IP PHF1 PRKAA2 RABGEF1 RACK1 RAD18 SMARCD1 STAM2 TNFAIP3 TOLLIP TRIM42 UBA52 UBAC1 UBASH3A UBE2D1 UBE2D2 UBE2E2 UBE2E3 UBQLN2 WWOX WWP1 WWP2 ZRANB1	30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 MAGEA4 MAP3K1 MAPK8 MLKL NBN ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7
Entrez ID		57561	56852
HPRD ID		09810	09242
Ensembl ID		ENSG00000113369	ENSG00000070950
Uniprot IDs		Q96B67	Q9NS91
PDB IDs		4N7H 4R7V 4R7X	2MRE 2MRF 2Y43 2YBF 5VF0
Enriched GO Terms of Interacting Partners?
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