RAD18 and MLKL

Data Source:
BioGRID (two hybrid)

		RAD18	MLKL
Description		RAD18 E3 ubiquitin protein ligase	mixed lineage kinase domain like pseudokinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Junction
	Molecular Function	Y-form DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding	Protein Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding
	Biological Process	DNA Repair Postreplication Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Protein Ubiquitination DNA Damage Response, Detection Of DNA Damage Protein Autoubiquitination Positive Regulation Of Chromosome Segregation Negative Regulation Of Cell Death	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Activation Of JNKK Activity Activation Of JUN Kinase Activity Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis
Pathways		Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins	TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798)	Testicular germ cell tumor ( 23666239)
Interacting Genes		30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 MAGEA4 MAP3K1 MAPK8 MLKL NBN ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7	7 interacting genes: ANAPC11 CDK1 NDUFB7 PSMB1 RAD18 S100A10 THOC3
Entrez ID		56852	197259
HPRD ID		09242	08752
Ensembl ID		ENSG00000070950	ENSG00000168404
Uniprot IDs		Q9NS91	Q8NB16
PDB IDs		2MRE 2MRF 2Y43 2YBF 5VF0	2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6O5Z 6UX8
Enriched GO Terms of Interacting Partners?
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