STAMBPL1 and ECSIT

Data Source:
BioGRID (two hybrid)

		STAMBPL1	ECSIT
Description		STAM binding protein like 1	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity	Protein Binding
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation Protein K63-linked Deubiquitination	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Metalloprotease DUBs	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS			Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		32 interacting genes: A2M CALCOCO2 CDC37 CEP72 ECSIT ENOX2 GCSAML GNPTAB GOLGA2 GOLGA6L9 IKZF3 INCA1 LAX1 MAGEA3 MAGEA6 MAST1 MORN5 PLEKHF2 PNMA1 PSEN1 RAB2A RAB2B REL RNF32 SF3B5 SMAD2 SMAD7 TCF4 TRIM27 TRIP13 ZNF835 ZRANB1	52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		57559	51295
HPRD ID		16486	12225
Ensembl ID		ENSG00000138134	ENSG00000130159
Uniprot IDs		Q96FJ0	Q9BQ95
PDB IDs		2ZNR 2ZNV
Enriched GO Terms of Interacting Partners?
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