ECSIT and IFIT3

Data Source:
BioGRID (two hybrid)

		ECSIT	IFIT3
Description		ECSIT signaling integrator	interferon induced protein with tetratricopeptide repeats 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Molecular_function RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Negative Regulation Of Cell Population Proliferation Response To Virus Cellular Response To Interferon-alpha Negative Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Hormone measurements ( 30576415)
Interacting Genes		52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	20 interacting genes: A2M APOE CYP2C8 DEUP1 ECSIT FANCA HAUS1 IFIT1 IFIT1B IFIT2 IFIT5 LONP1 LVRN MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM1 TPM3
Entrez ID		51295	3437
HPRD ID		12225	05228
Ensembl ID		ENSG00000130159	ENSG00000119917
Uniprot IDs		Q9BQ95	O14879 Q5T765
PDB IDs			6C6K
Enriched GO Terms of Interacting Partners?
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