MIB1 and UBE2W

Data Source:
BioGRID (two hybrid)

		MIB1	UBE2W
Description		MIB E3 ubiquitin protein ligase 1	ubiquitin conjugating enzyme E2 W
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle	Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Severe progression in rheumatoid arthritis ( 29065906)	Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)
Interacting Genes		15 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W	78 interacting genes: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4
Entrez ID		57534	55284
HPRD ID		06660	07724
Ensembl ID		ENSG00000101752	ENSG00000104343
Uniprot IDs		Q86YT6	Q96B02 Q96FI0 X6REH9
PDB IDs		4TSE 4XI6 4XI7 4XIB	2A7L 2MT6
Enriched GO Terms of Interacting Partners?
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