UBE2W and TRIM59

Data Source:
BioGRID (two hybrid)

		UBE2W	TRIM59
Description		ubiquitin conjugating enzyme E2 W	tripartite motif containing 59
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		78 interacting genes: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4	26 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PLLP RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		55284	286827
HPRD ID		07724	15568
Ensembl ID		ENSG00000104343	ENSG00000213186
Uniprot IDs		Q96B02 Q96FI0 X6REH9	Q8IWR1
PDB IDs		2A7L 2MT6
Enriched GO Terms of Interacting Partners?
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