CBX8 and MLLT3

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		CBX8	MLLT3
Description		chromobox 8	MLLT3 super elongation complex subunit
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Chromosome Cytosol Transcription Elongation Factor Complex Extracellular Exosome
	Molecular Function	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity	DNA Binding Chromatin Binding Protein Binding Histone Binding Lysine-acetylated Histone Binding Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Segment Specification Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated Hematopoietic Stem Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chromatin Organization Regulation Of Stem Cell Division Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Plateletcrit ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)	Atrial fibrillation ( 29892015) Dietary fat liking ( 32516399) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Platelet distribution width ( 32888494) Response to montelukast in asthma (change in FEV1) ( 26083242) Systolic blood pressure ( 30578418)
Interacting Genes		87 interacting genes: ABLIM3 BACH2 BANP BMI1 CALCOCO2 CARD10 CARD9 CCDC136 CCDC57 CEP70 DVL3 EEF1G FHL3 FSD2 FXR1 GIGYF1 GOLGA2 GOLGA6L9 GPRASP2 GRIPAP1 H3-4 HAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 JADE2 JAKMIP1 KANK2 KAT5 KAT7 KCTD9 KIFC3 KRT31 KRT34 KRT40 LSM2 LZTS2 MB21D2 MCC MDFI MID2 MLLT1 MLLT3 MTUS2 NAB2 PAXIP1 PCGF5 PHACTR1 PIBF1 PICK1 PIH1D2 PLEKHF2 PNMA1 PNMA2 POLR1C PRDM6 PRKAR1B RASSF3 RING1 RPGRIP1 SESTD1 SETDB1 SOX5 TAX1BP1 TEPSIN TFCP2 TFIP11 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC22D4 TSGA10 TTC23 UNC119 USH1G USP11 USP7 VIM ZBTB14 ZBTB8A ZBTB9 ZNF185 ZRANB1	19 interacting genes: AFF1 ALKBH4 APP APPBP2 BCOR CBX8 CDK6 EEF1A1 FAM9A H3C1 LRIF1 LRRK2 MCM6 MIIP PTN RBM48 SGK1 VAX1 ZNF572
Entrez ID		57332	4300
HPRD ID		13006	01163
Ensembl ID		ENSG00000141570	ENSG00000171843
Uniprot IDs		Q9HC52	A0A0S2Z448 P42568
PDB IDs		2N4Q 3I91 5EQ0	2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6L5Z 6MIL 6MIM
Enriched GO Terms of Interacting Partners?
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