VANGL2 and DVL1

Data Source:
HPRD (in vitro)

		VANGL2	DVL1
Description		VANGL planar cell polarity protein 2	dishevelled segment polarity protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane	Cytosol Microtubule Postsynaptic Density Lateral Plasma Membrane Clathrin-coated Vesicle Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Wnt Signalosome
	Molecular Function	Protein Binding	Molecular_function Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Heart Looping Cell Migration Involved In Kidney Development Apical Protein Localization Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-motile Cilium Assembly	Regulation Of Neurotransmitter Levels Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Presynapse Assembly Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		PCP/CE pathway Asymmetric localization of PCP proteins	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left-handedness ( 32989287) Multiple sclerosis ( 31604244 24076602) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)	Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: AP1M1 ARFRP1 DVL1 MAGI3 SQSTM1	43 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 HDHD2 HECW1 KLHL12 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 TRIM69 USP13 VANGL1 VANGL2
Entrez ID		57216	1855
HPRD ID		02758	03220
Ensembl ID		ENSG00000162738	ENSG00000107404
Uniprot IDs		A8K4L6 Q9ULK5	O14640
PDB IDs			6TTK
Enriched GO Terms of Interacting Partners?
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