SMURF1 and EPN1

Data Source:
BioGRID (enzymatic study)

		SMURF1	EPN1
Description		SMAD specific E3 ubiquitin protein ligase 1	epsin 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Exosome	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Phospholipid Binding Activin Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding	Protein Binding Phospholipid Binding Clathrin Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Protein Ubiquitination Cell Differentiation BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Receptor Catabolic Process Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Engulfment Of Target By Autophagosome Substrate Localization To Autophagosome Protein Targeting To Vacuole Involved In Autophagy Protein Localization To Plasma Membrane Positive Regulation Of Dendrite Extension Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 28067908 23128233) Lack of premeditation ( 30718321) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Ulcerative colitis ( 28067908 20228798)	Major depressive disorder ( 23377640)
Interacting Genes		189 interacting genes: ADRM1 ANAPC5 ANKRD13A ANKRD13D ANKRD50 ANKS4B ANXA6 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASCC2 ASH2L ATXN3 AVEN AXIN1 BMPR2 BTK BTRC C9orf78 CALCOCO1 CCDC69 CCM2 CDC40 CDK14 CDKL1 CSNK1D CSNK2A2 CTNNB1 CTNND1 CTTN CUEDC1 CUL5 CXXC1 DDX54 DNAJC7 DUSP13 DVL2 ECSIT ELOF1 ELP3 ENTR1 EPHA1 EPN1 ETV6 FAF2 FBXL15 FBXO3 FBXO30 FCHO1 FES FGF12 FGR FKBP3 FSCN1 FZR1 GNG11 GRIPAP1 GRK3 HDGFL3 HIP1 HOMER2 ILRUN IMPACT ING2 INPP5B IRAK2 ITGB1BP1 ITK JUNB KRT36 LATS1 LCK LHX9 LIMS1 LMNA LONRF3 MAP3K10 MAP3K2 MAP3K3 MAP3K9 MAP4K5 MARK2 MATK MINDY3 MSN NAA16 NDFIP2 NEDD8 NEK2 ODF2 OTUD6B OXSR1 PADI4 PAK1 PAK1IP1 PDGFRA PDLIM7 PICALM PIP5K1C PLEKHO1 POLR2A PRKCA PRKCG PRKCI PRR16 PSMD4 PSME3 PWP1 RABEP1 RAD23A RASD2 RBCK1 RHOA RHOB RHPN2 RIOK3 RIPK2 RIT1 RNF11 RNF114 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SCYL1 SENP8 SF3A1 SLAIN2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SPART SQSTM1 SRSF4 SRSF5 STK31 STK35 STRAP STUB1 TAB1 TAOK3 TBK1 TLN1 TNIK TNIP2 TNK2 TNNT1 TOM1 TOM1L2 TPM4 TRAF4 TRIP10 TTC17 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2K UBE2L3 UBE2M UBE2V1 UBQLN1 UBQLN2 UBTF UBXN1 UBXN6 UBXN7 USP45 USP5 USP9X WDR61 WEE1 WFS1 XPO1 ZFAND5	25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16
Entrez ID		57154	29924
HPRD ID		06902	06270
Ensembl ID		ENSG00000198742	ENSG00000063245
Uniprot IDs		Q9HCE7	A0A024R4S1 Q9Y6I3
PDB IDs		2LAZ 2LB0 2LB1 2LTX 3PYC	1INZ 1KYD
Enriched GO Terms of Interacting Partners?
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