MLKL and NDUFB7

Data Source:
BioGRID (two hybrid)

		MLKL	NDUFB7
Description		mixed lineage kinase domain like pseudokinase	NADH:ubiquinone oxidoreductase subunit B7
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Junction	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space
	Molecular Function	Protein Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Activation Of JNKK Activity Activation Of JUN Kinase Activity Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Respiratory Chain Complex I Assembly
Pathways		TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Interacting Genes		7 interacting genes: ANAPC11 CDK1 NDUFB7 PSMB1 RAD18 S100A10 THOC3	41 interacting genes: AGBL2 ANKRD36B ATG9A C1orf109 CAPN1 CCDC24 CCNC CDCA7L CDKN2D CHIC2 CINP CKAP4 CTNNA3 ENKD1 FAM161B FAM90A1 GEM GPATCH2L GYS1 KRTAP10-10 LMO2 MAGOHB MAK MEIS2 MKRN3 MLKL NDUFB2 NFKBIB NFKBID RCOR3 RECK RIPPLY1 RIPPLY2 SCNM1 SPRED2 STRA6 TLE5 ZNF330 ZNF417 ZNF564 ZNF587
Entrez ID		197259	4713
HPRD ID		08752	11957
Ensembl ID		ENSG00000168404	ENSG00000099795
Uniprot IDs		Q8NB16	P17568
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6O5Z 6UX8	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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