PSEN2 and RAB11A

Data Source:
HPRD (two hybrid, in vivo)

		PSEN2	RAB11A
Description		presenilin 2	RAB11A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Kinetochore Nucleus Nuclear Inner Membrane Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Apical Plasma Membrane Z Disc Growth Cone Neuromuscular Junction Protein-containing Complex Ciliary Rootlet Neuronal Cell Body Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Gamma-secretase Complex	Spindle Pole Endosome Multivesicular Body Golgi Apparatus Trans-Golgi Network Centrosome Kinetochore Microtubule Cytosol Transport Vesicle Axon Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Recycling Endosome Glutamatergic Synapse
	Molecular Function	Endopeptidase Activity Protein Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving	GTPase Activity Protein Binding GTP Binding Microtubule Binding Syntaxin Binding Myosin V Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Calcium Ion Transport Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Ephrin Receptor Signaling Pathway Amyloid-beta Metabolic Process Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Renal Water Homeostasis Exocytosis Mitotic Metaphase Plate Congression Positive Regulation Of Epithelial Cell Migration Regulation Of Multivesicular Body Size Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Astral Microtubule Organization Neuron Projection Development Melanosome Transport Regulation Of Cytokinesis Protein Localization To Cell Surface Multivesicular Body Assembly Post-translational Protein Modification Positive Regulation Of Axon Extension Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Protein Transport Establishment Of Vesicle Localization Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization To Organelle Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Amyloid-beta Clearance By Transcytosis Positive Regulation Of Protein Localization To Plasma Membrane Exosomal Secretion
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3	Translocation of SLC2A4 (GLUT4) to the plasma membrane Vasopressin regulates renal water homeostasis via Aquaporins Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation
Drugs			5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate
Diseases		Alzheimer's disease (AD)
GWAS		Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	32 interacting genes: ARF5 ARF6 CHMP1B CHMP3 DTNBP1 GDI2 IKBKG KAT2B MYO5A MYO5B OPTN PPP2R1A PPP2R1B PSEN1 PSEN2 PTGIR RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP4 RAB11FIP5 RAB13 RAB3IL1 RAB3IP RAB8A RABGGTB RCHY1 SEC13 STX4 TBXA2R TDP2 WDR44
Entrez ID		5664	8766
HPRD ID		02860	05715
Ensembl ID		ENSG00000143801	ENSG00000103769
Uniprot IDs		P49810	A0A024R5Z8 P62491
PDB IDs			1OIV 1OIW 1OIX 1YZK 2D7C 2GZD 2GZH 2HV8 4C4P 4D0L 4D0M 4LWZ 4LX0 4UJ3 4UJ4 4UJ5 5C46 5C4G 5EUQ 5EZ5 5FBL 5FBQ 5FBR 5FBV 5FBW 5JCZ 6DJL 6IXV
Enriched GO Terms of Interacting Partners?
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