RAB11A and RAB11FIP5

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		RAB11A	RAB11FIP5
Description		RAB11A, member RAS oncogene family	RAB11 family interacting protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Endosome Multivesicular Body Golgi Apparatus Trans-Golgi Network Centrosome Kinetochore Microtubule Cytosol Transport Vesicle Axon Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Recycling Endosome Glutamatergic Synapse	Golgi Membrane Mitochondrion Mitochondrial Outer Membrane Early Endosome Golgi Apparatus Secretory Granule Transport Vesicle Membrane Early Endosome Membrane Centriolar Satellite Intracellular Membrane-bounded Organelle Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding Syntaxin Binding Myosin V Binding	Protein Binding Gamma-tubulin Binding
	Biological Process	Renal Water Homeostasis Exocytosis Mitotic Metaphase Plate Congression Positive Regulation Of Epithelial Cell Migration Regulation Of Multivesicular Body Size Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Astral Microtubule Organization Neuron Projection Development Melanosome Transport Regulation Of Cytokinesis Protein Localization To Cell Surface Multivesicular Body Assembly Post-translational Protein Modification Positive Regulation Of Axon Extension Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Protein Transport Establishment Of Vesicle Localization Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization To Organelle Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Amyloid-beta Clearance By Transcytosis Positive Regulation Of Protein Localization To Plasma Membrane Exosomal Secretion	Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulated Exocytosis Negative Regulation Of Adiponectin Secretion Cellular Response To Acidic PH Regulation Of Protein Localization To Cell Surface
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Vasopressin regulates renal water homeostasis via Aquaporins Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Non-word reading ( 30741946) Pediatric areal bone mineral density (spine vs radius & hip discordant skeletal phenotype) ( 29240982) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		32 interacting genes: ARF5 ARF6 CHMP1B CHMP3 DTNBP1 GDI2 IKBKG KAT2B MYO5A MYO5B OPTN PPP2R1A PPP2R1B PSEN1 PSEN2 PTGIR RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP4 RAB11FIP5 RAB13 RAB3IL1 RAB3IP RAB8A RABGGTB RCHY1 SEC13 STX4 TBXA2R TDP2 WDR44	9 interacting genes: ARF6 NAPG RAB11A RAB11B RAB11FIP4 RAB14 RAB25 RO60 YWHAG
Entrez ID		8766	26056
HPRD ID		05715	16117
Ensembl ID		ENSG00000103769	ENSG00000135631
Uniprot IDs		A0A024R5Z8 P62491	Q9BXF6 Q9UFM0
PDB IDs		1OIV 1OIW 1OIX 1YZK 2D7C 2GZD 2GZH 2HV8 4C4P 4D0L 4D0M 4LWZ 4LX0 4UJ3 4UJ4 4UJ5 5C46 5C4G 5EUQ 5EZ5 5FBL 5FBQ 5FBR 5FBV 5FBW 5JCZ 6DJL 6IXV
Enriched GO Terms of Interacting Partners?
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