PRTN3 and IL32

Data Source:
HPRD (in vitro)

		PRTN3	IL32
Description		proteinase 3	interleukin 32
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Plasma Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Cytosol Membrane
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding	Cytokine Activity Protein Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Phagocytosis Blood Coagulation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation	Defense Response Immune Response Cell Adhesion Cytokine-mediated Signaling Pathway
Pathways		Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides	Other interleukin signaling
Drugs		Elafin
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Monocyte percentage of white cells ( 32888494 27863252) White blood cell count (basophil) ( 27863252)	HIV-1 susceptibility ( 22174851)
Interacting Genes		13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF	11 interacting genes: C1QB HSPA8 KPNA5 NDN NQO2 PRTN3 RHBDD2 RPL4 SNRNP70 TUT1 ZFPM2
Entrez ID		5657	9235
HPRD ID		01512	09346
Ensembl ID		ENSG00000196415	ENSG00000008517
Uniprot IDs		P24158	P24001
PDB IDs		1FUJ
Enriched GO Terms of Interacting Partners?
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