PRTN3 and SERPINB1

Data Source:
HPRD (in vitro)

		PRTN3	SERPINB1
Description		proteinase 3	serpin family B member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Plasma Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Membrane Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Phagocytosis Blood Coagulation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Interleukin-1 Beta Production Neutrophil Degranulation Type B Pancreatic Cell Proliferation
Pathways		Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides	Neutrophil degranulation
Drugs		Elafin
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Monocyte percentage of white cells ( 32888494 27863252) White blood cell count (basophil) ( 27863252)	BMI at 5 years old ( 31575865) Cerebrospinal fluid AB1-42 levels ( 28247064)
Interacting Genes		13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF	4 interacting genes: CDC42 ELANE PRTN3 XPO1
Entrez ID		5657	1992
HPRD ID		01512	00555
Ensembl ID		ENSG00000196415	ENSG00000021355
Uniprot IDs		P24158	P30740 V9HWH1
PDB IDs		1FUJ	4GA7
Enriched GO Terms of Interacting Partners?
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