CCL28 and PF4

Data Source:
BioGRID (pull down, pull down)

		CCL28	PF4
Description		C-C motif chemokine ligand 28	platelet factor 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Symbiont-containing Vacuole Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Chemokine Activity	Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Cell Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling	Platelet Degranulation Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Leukocyte Chemotaxis Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs			Drotrecogin alfa Heparin
Diseases
GWAS		Metabolite levels (X-11787) ( 23934736) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		26 interacting genes: ACKR2 CCL11 CCL13 CCL17 CCL21 CCL26 CCL5 CCR10 CCR3 CXCL10 CXCL12 CXCL13 CXCL14 CXCL17 CXCL2 CXCL9 DDI1 DYNLT3 PF4 PF4V1 PPBP PSMA3 STUB1 TSC1 XCL1 XCL2	28 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN XCL1 XCL2
Entrez ID		56477	5196
HPRD ID		05577	01426
Ensembl ID		ENSG00000151882	ENSG00000163737
Uniprot IDs		A0N0Q3 D6RC73 Q9NRJ3	P02776
PDB IDs		6CWS	1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU
Enriched GO Terms of Interacting Partners?
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