PRMT8 and DCAF8

Data Source:
BioGRID (two hybrid)

		PRMT8	DCAF8
Description		protein arginine methyltransferase 8	DDB1 and CUL4 associated factor 8
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Anchored Component Of The Cytoplasmic Side Of The Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity S-adenosyl-L-methionine Binding	Protein Binding
	Biological Process	Protein Methylation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Arginine Methylation Regulation Of Protein Binding Protein Homooligomerization	Protein Ubiquitination Post-translational Protein Modification
Pathways			Neddylation
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 31014085) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) HDL cholesterol ( 19060911)	Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		22 interacting genes: CARM1 CEP162 COIL DCAF8 EWSR1 FBL FYN GPATCH2L H4C1 KRTAP6-3 OFCC1 PIK3R1 PLCG1 PPARA PRMT1 PRMT2 SERBP1 SYNCRIP TNPO2 UBL5 VHL ZNF451	12 interacting genes: DDB1 GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBPMS SUV39H1 THAP1 TNS2 TRIM54
Entrez ID		56341	50717
HPRD ID		11029	18300
Ensembl ID		ENSG00000111218	ENSG00000132716
Uniprot IDs		Q59GT2 Q9NR22	B7Z8C9 Q5TAQ9
PDB IDs		4X41 5DST	3I8E
Enriched GO Terms of Interacting Partners?
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