CENPJ and CIC

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		CENPJ	CIC
Description		centromere protein J	capicua transcriptional repressor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Microtubule Plasma Membrane Gamma-tubulin Small Complex	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Astral Microtubule Nucleation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Centriole Replication Microtubule Polymerization Cell Division Cilium Assembly Centriole Elongation Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization	Regulation Of Transcription By RNA Polymerase II Brain Development Learning Memory Social Behavior Negative Regulation Of Transcription, DNA-templated
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2
Drugs
Diseases		Seckel syndrome Primary microcephaly (MCPH)
GWAS			Bitter alcoholic beverage consumption ( 31046077) Neutrophil count ( 32888494)
Interacting Genes		15 interacting genes: ATN1 BCCIP CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH STAT5A STAT5B TUBG1 YWHAG YWHAZ	13 interacting genes: ATXN1 CENPJ CSNK2B GABPB1 GOLGA2 GTPBP3 NFYC PICK1 POLR1H PYCR2 SEC62 SETD2 TRIM22
Entrez ID		55835	23152
HPRD ID		09876	10831
Ensembl ID		ENSG00000151849	ENSG00000079432
Uniprot IDs		A8K8P1 F6VUX8 Q9HC77	A0A0A0MQR4 Q96RK0
PDB IDs		5EIB 5ITZ	2M41 4J2J 4J2L 6JRP 6KZG 6KZH
Enriched GO Terms of Interacting Partners?
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