DCP1A and NSMAF

Data Source:
BioGRID (two hybrid, pull down)

		DCP1A	NSMAF
Description		decapping mRNA 1A	neutral sphingomyelinase activation associated factor
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	Cytoplasm Cytosol
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Enzyme Regulator Activity Identical Protein Binding	Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Protein Localization To Cytoplasmic Stress Granule	Ceramide Metabolic Process Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Ceramide Biosynthetic Process
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	TNFR1-mediated ceramide production
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)	Basophil count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG	6 interacting genes: ACTB CD40 DCP1A DCP1B RACK1 TNFRSF1A
Entrez ID		55802	8439
HPRD ID		06113	09117
Ensembl ID		ENSG00000272886	ENSG00000035681
Uniprot IDs		Q9NPI6	Q92636
PDB IDs		2WX3 4B6H
Enriched GO Terms of Interacting Partners?
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