TMEM30A and SPP1

Data Source:
BioGRID (two hybrid)

		TMEM30A	SPP1
Description		transmembrane protein 30A	secreted phosphoprotein 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Transport Vesicle Membrane Azurophil Granule Membrane Specific Granule Membrane Phospholipid-translocating ATPase Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Aminophospholipid Flippase Activity	Cytokine Activity Integrin Binding Protein Binding Extracellular Matrix Binding
	Biological Process	Drug Transmembrane Transport Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Protein Localization To Endosome Neutrophil Degranulation Phospholipid Translocation Positive Regulation Of Phospholipid Translocation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Aminophospholipid Translocation	Osteoblast Differentiation Androgen Catabolic Process Inflammatory Response Cell Adhesion Signal Transduction Embryo Implantation Extracellular Matrix Organization Biomineral Tissue Development Response To Vitamin D Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Positive Regulation Of Estradiol Secretion
Pathways		Neutrophil degranulation	Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Dental caries ( 23064961) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: APP GPR182 MAL SPP1 TRIM54	97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		55754	6696
HPRD ID		15535	01325
Ensembl ID		ENSG00000112697	ENSG00000118785
Uniprot IDs		Q9NV96	A0A024RDE2 A0A024RDE6 A0A024RDJ0 B7Z351 P10451 Q3LGB0
PDB IDs		6K7G 6K7H 6K7I 6K7J 6K7K 6K7L 6K7M 6K7N 6LKN 7BSP 7BSQ 7BSS 7BSU 7BSV 7BSW	3CXD 3DSF
Enriched GO Terms of Interacting Partners?
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