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SPP1 and USP42
Data Source:
BioGRID
(two hybrid)
SPP1
USP42
Description
secreted phosphoprotein 1
ubiquitin specific peptidase 42
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Apparatus
Cell Projection
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Cytokine Activity
Integrin Binding
Protein Binding
Extracellular Matrix Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Biological Process
Osteoblast Differentiation
Androgen Catabolic Process
Inflammatory Response
Cell Adhesion
Signal Transduction
Embryo Implantation
Extracellular Matrix Organization
Biomineral Tissue Development
Response To Vitamin D
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Bone Resorption
Positive Regulation Of Transcription, DNA-templated
Decidualization
Response To Steroid Hormone
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Cellular Response To Testosterone Stimulus
Positive Regulation Of Estradiol Secretion
Ubiquitin-dependent Protein Catabolic Process
Spermatogenesis
Protein Deubiquitination
Protein Phosphopantetheinylation
Cell Differentiation
Regulation Of Apoptotic Process
Pathways
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation
Ub-specific processing proteases
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Dental caries (
23064961
)
Urate levels (
31578528
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Interacting Genes
97 interacting genes:
ABCF3
ACP5
AFF4
AMOTL2
APOA1
ATP2A2
ATP5PB
BAG6
BRD3
C1RL
C2orf50
CACNG4
CALM1
CC2D1B
CCR8
CD44
CEP162
CHD1
CISD2
CMTM3
COMMD1
COPS5
CSNK2A1
CSNK2A2
CTNNBL1
CYB5R3
DCX
DNAJB1
DNTTIP2
DRD2
DSEL
EEF1A1
EIF3K
EPAS1
ERBB2
F2
FTH1
GET3
GRIPAP1
HBA2
HMGN1
IGFBP5
ITGA5
ITGA9
ITGAV
ITGB1
ITGB5
KCNIP1
LRRC4
MAP1A
MAP1B
MARCKS
MEOX2
MMP3
MMP7
MPPED1
MRPL23
NACA
NCKAP1
NCS1
NCSTN
PDLIM7
PEMT
PEPD
PLD3
PRKACB
PRKCA
PRKG1
PTGER4
RANBP9
RAPGEF2
RBBP6
RIMS4
RPL13
RPL15
RPL5
RPS13
SEC24C
SGTA
SGTB
SLC22A1
SLC39A6
SNAPIN
SSB
STAU1
STK39
TBC1D8
TMEM168
TMEM30A
TPT1
TTC1
TUBB
UBQLN4
USP42
USP8
ZNF638
ZNF804A
4 interacting genes:
HRAS
SPP1
TP53
UBC
Entrez ID
6696
84132
HPRD ID
01325
18879
Ensembl ID
ENSG00000118785
ENSG00000106346
Uniprot IDs
A0A024RDE2
A0A024RDE6
A0A024RDJ0
B7Z351
P10451
Q3LGB0
Q9H9J4
PDB IDs
3CXD
3DSF
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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