VAC14 and CRK

Data Source:
BioGRID (two hybrid)

		VAC14	CRK
Description		VAC14 component of PIKFYVE complex	CRK proto-oncogene, adaptor protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extrinsic Component Of Vacuolar Membrane Endoplasmic Reticulum Cytosol Endosome Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle PAS Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	Phosphotyrosine Residue Binding Insulin-like Growth Factor Receptor Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Kinase Binding Signaling Receptor Complex Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Self-association Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Viral Process Positive Regulation Of Kinase Activity	Activation Of MAPKK Activity Neuron Migration Response To Yeast Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Regulation Of Cell Shape Regulation Of Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Rac Protein Signal Transduction Helper T Cell Diapedesis Response To Hepatocyte Growth Factor Reelin-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Hydrogen Peroxide Regulation Of GTPase Activity Regulation Of Protein Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Dendrite Development Cell Chemotaxis Negative Regulation Of Wound Healing Response To Cholecystokinin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Nitric Oxide Activation Of GTPase Activity Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Endothelin Negative Regulation Of Cell Motility Regulation Of T Cell Migration
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)	Atrial fibrillation ( 30061737) Granulocyte count ( 27863252) Intraocular pressure ( 30591961) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 28135244 27841878 30578418)
Interacting Genes		107 interacting genes: ABHD11 ACSS1 AMT APP ARID5A ASB13 BCL2L1 BHLHE40 C11orf54 C19orf54 C2CD6 C4orf33 CASP1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FIG4 FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPRYD7 SRPK2 TCEANC TEX37 TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34 ZNF720	169 interacting genes: ABL1 ABL2 ANKZF1 ANLN AR ARHGAP17 ARHGAP32 ASAP1 ASAP3 ASCL4 ATF3 ATXN1 AVIL BATF3 BCAR1 BCR BEX5 BUB1 C1orf94 C4orf17 C6orf141 CBL CBLB CBLC CHTF18 CLNK CNDP2 CORO6 CRKL DAB1 DOCK1 DOCK3 DOK1 DOK2 DOK3 DOK4 DOK7 DPPA4 EFS EGFR ELK1 ELK3 EPHA3 EPHB2 EPHB3 EPHB6 EPS15 EPYC ERBB2 ERBB3 ERBB4 ESD EYA3 FASLG FER FGFR1 FLACC1 FLT1 FRS2 FSTL1 FYN GAB1 GABPB2 GAREM1 GRB2 HABP4 HSH2D IFT140 IGF1R IKZF3 INO80E INSR IRS1 IRS2 IRS4 ISL1 KCTD13 KCTD17 KDR KHDRBS1 KIT KLF15 KLHL20 LASP1 LHX8 LNX2 MAGEC3 MAP4K1 MAP4K5 MAPK4 MAPK8 MET MICAL1 MNDA MPG MYLIP MYOZ2 NCK1 NEDD9 NTRK1 NUFIP2 OFCC1 PAFAH1B2 PDGFRA PDGFRB PHC2 PIK3R1 PIK3R2 PIK3R3 PLSCR1 POT1 PPFIBP2 PPP1CA PRKACA PRRC2B PRRG2 PSMC1 PSMC6 PTK2 PTK2B PTPN1 PTPN4 PTPRH PTTG1 PXN RAB2B RAPGEF1 REPS1 RET RIN3 RTCB RYBP SASH1 SAXO1 SEMA4D SEPTIN6 SETD9 SH2D2A SH3BP1 SHB SHC1 SOCS1 SOCS6 SOS1 SPRR2A STAT4 STAT5A STAT5B STRN4 SYN1 TCAP TDG TERF2IP TM4SF19 TP53 TP53BP2 TUBA1C TWIST2 TXK USP53 VAC14 VAV1 WASF1 WDR83 WEE1 XPO1 ZAP70 ZKSCAN7 ZNF557
Entrez ID		55697	1398
HPRD ID		07660	01267
Ensembl ID		ENSG00000103043	ENSG00000167193
Uniprot IDs		Q08AM6	A0A0S2Z3K9 A0A0S2Z3Q4 L7RT18 P46108
PDB IDs			1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ 2MS4 5UL6 6ATV
Enriched GO Terms of Interacting Partners?
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